The roots of Cannabidiol (CBD) extend back thousands of years; to the end of the first ice age, Archaeological finds suggest that Cannabis Sativa, was likely one of the first agricultural crops planted by early man. In fact, growing Cannabis Sativa, something we tend to think of as modern, is often associated with the birth of agriculture 12,000 to 10,000 years ago.
Cannabis (or hemp) plants are exceptionally versatile. Both the seeds and oil were used for food in China as early as 6,000 BCE. Two thousand years later, in 4,000 BCE, there is evidence of textiles made from hemp used in both China and Turkestan. The influence of the plant seems to have been global. In 850, the Vikings transported hemp rope and seeds to Iceland, and by the year 900, Arabs were learning techniques for making paper from hemp. By 1000, Italians were using ropes made of hemp on their sailing ships.
Today, consumers are primarily interested in the healthful properties of cannabis compounds, and there is a long thread of cannabis applications for healing running through all eras of history. Stories about the healing properties of cannabis are mention by Greek philosophers | Herodotus | Napoleon and other legendary figures. The physician for Nero’s army, for example, included cannabis in his medical inventory.
In 1563, the medicinal benefits of cannabis were discussed in a report by Portuguese physician Garcia da Orta. A few years later, China's Li Shih-Chen documented the antibiotic and anti-nausea effects of cannabis.
In contrast to today’s modern restrictions of growing Cannabis Sativa, King Henry VIII actually fined farmers if they DID NOT raise hemp for industrial use.
Less than one hundred years later, settlers in Jamestown, Virginia--The New World--began growing hemp plants for hemp’s unusually strong fibre. Once the plant demonstrated its usefulness, it became illegal to NOT grow hemp in Virginia.
By 1850, Cannabis was added to list of The U.S Pharmacopeia, a respected compendium (com-pen-dium) of Medicines and Dietary Supplements. That same year, cannabis was used throughout United States as a medicinal drug and could easily be purchased in pharmacies and general stores. This lasted until about 1915.
On a side note, hemp for almost two decades, has been growing in the abandoned Chernobyl Nuclear Power Plant in the Ukraine as it actually helps to reduce the soil toxicity. It literally sucks toxins out of the soil & pollution out of the air cleaning the whole environment, what other crop does that?
Many people assume that CBD is a rather new and innovative supplement, but CBD history actually goes back much further.
Actually, CBD as we know it today has been around for more than half a century.
The first person who successfully extracted CBD from Cannabis Sativa was a chemist who graduated from Harvard university, Roger Adams. However, when Adams first managed this in 1940 he wasn’t aware he succeeded in extracting a chemical compound and didn’t actually know what he had done. Years later, Adams and other scientists realized what in-fact he had accomplished and started researching the possible benefits of CBD.
Modern CBD history really begins in 1946, when Dr. Walter S. Loewe conducted the first CBD test on lab animals. These tests gave proof that CBD doesn’t cause an altered mental state.
That same year Dr. Raphael Mechoulam identified CBD’s three-dimensional structure, that’s actually why he’s often credited as the scientist who discovered CBD.
Further research continued in the 1960s on primates then finally, the first CBD oil meant for therapeutic use was released by The British Pharmacopoeia.
In the next few decades, the research continued. In 1980, Dr. Mechoulam made another breakthrough in CBD history when he ran a study which showed cannabidiol could be a key factor in treating epilepsy.
In 1990, it was announced that a team lead by Lisa Matsuda at the National Institute of Mental health had mapped the DNA sequence that encodes a cannabinoid receptor in the brain.
Matsuda was also able to clone this receptor.
This opened doors and lead to the development in knockout mice that lacked this certain protein receptor.
When THC (THC is the compound that gets you “high”) was administered to the knockout mice it was shown that THC had no effect, proving THC works by activating cannabinoid receptors in the brain.
A second cannabinoid receptor named CB2 was also identified at this time, they are located throughout the immune system and the peripheral nervous system.
The discovery of these receptors resulted in the uncovering of naturally occurring neurotransmitters called endocannabinoids.
There are dozens of endocannabinoids that have been identified, along with another dozen protein receptors that interact with these endocannabinoids.
In the pursuit of unearthing the metabolic pathways of phytocannabinoids….
(Phytocannabinoids are cannabinoids from an external source, like The Wee Hemp Company sell), the scientists came across an unknown molecular signalling system within the body that is involved in regulating a broad range of biological functions. This system was named the endocannabinoid system (ECS).